The ABCB1 3435C > T polymorphism influences docetaxel transportation in ovarian cancer
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چکیده
منابع مشابه
Meta-Analysis of ABCB1 3435C>T Polymorphism and Colorectal Cancer
OBJECTIVE Many studies have focused on the association between the ABCB1 3435C>T polymorphism and colorectal cancer (CRC) risk. However, the results were conflicting. The aim of this meta-analysis is to evaluate the precise association between this polymorphism and CRC risk. METHODS We formally reviewed the literature at Pubmed, EMBASE and the Cochrane Library with the key words as follows: A...
متن کاملAssociation of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility.
Infertility is a common problem affecting one in six couples, and in 30% of infertile couples, the male factor is a major cause due to defective sperm quality. P-glycoprotein (P-gp), a product of the MDR1 (ABCB1) gene, may be a link between genetic and environmental factors contributing to the development of male infertility because pesticides (P-gp substrates) are well established factors of m...
متن کاملABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.
P-glycoprotein (P-gp), encoded by the ABCB1 gene, confers multi-drug resistance to a variety of antineoplastic agents, for example, paclitaxel. Recently, the G1199T/A polymorphism in the ABCB1 gene was shown to be important for the function of P-gp as well as for the resistance to several chemotherapeutic agents in vitro. We analyzed the allelic distribution of the G1199T/A and other polymorphi...
متن کاملFirst report on the distribution of 3435C>T ABCB1/MDR1polymorphism in healthy Bosniak population.
Grażyna ADLER*, Anna PAWIŃSKA-MATECKA, Agnieszka GARSTKA, Nermin Nusret SALKIC, Amina VALJEVAC, Beata KARAKIEWICZ 1 Department of Gerontobiology, Pomeranian Medical University, Szczecin, Poland 2 Central Laboratory, Regional Hospital, Szczecin, Poland 3 Department of Gastroenterology and Hepatology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina 4 Laboratory for Molecular Medic...
متن کاملABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy
Expression of the adenosine triphosphate-binding cassette B1 (ABCB1) transporter and P-glycoprotein are associated with resistance to anticancer drugs. The purpose of this study was to investigate the role of single nucleotide polymorphism in the ABCB1 and CYP3A genes in breast cancer patients who were treated with neoadjuvant chemotherapy. Stage II/III breast cancer patients were treated with ...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 2019
ISSN: 0300-0605,1473-2300
DOI: 10.1177/0300060519870354